Targets of Amitriptyline
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
4-nitrophenol 2-hydroxylase No
5HT transporter No
Adenylate cyclase type 1 No
Albendazole monooxygenase No
Alpha-2A adrenergic receptor Yes
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIID6 No
Cytochrome P450 Yes
Cytochrome P450 2D6 No
Cytochrome P-450 II C No
Cytochrome P450db1 No
D(1A) dopamine receptor Yes
D(1B) dopamine receptor No
D(2) dopamine receptor Yes
D(3) dopamine receptor Yes
G-protein coupled receptor 97 No
Histamine H1 receptor No
Histamine H2 receptor No
Monoamine transporter Yes
NET Yes
Potassium voltage-gated channel subfamily H member 2 No
Potassium voltage-gated channel subfamily KQT member 2 Yes
Sodium-dependent noradrenaline transporter No
Sodium-dependent serotonin transporter No
5-hydroxytryptamine 2A receptor No
5-hydroxytryptamine 1A receptor No
Delta-type opioid receptor No
Kappa-type opioid receptor Yes
High affinity nerve growth factor receptor Yes
BDNF/NT-3 growth factors receptor Yes
Alpha-1A adrenergic receptor No
Alpha-1D adrenergic receptor No
Muscarinic acetylcholine receptor M1 No
Muscarinic acetylcholine receptor M2 No
Muscarinic acetylcholine receptor M3 No
Muscarinic acetylcholine receptor M4 No
Muscarinic acetylcholine receptor M5 No
Potassium voltage-gated channel subfamily A member 1 Yes
Potassium voltage-gated channel subfamily D member 2 No
Potassium voltage-gated channel subfamily D member 3 No
serotonin transporter inhibitor No
noradrenalin transporter inhibitor No

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