Detail for rifampin
Basic Information
DrugID 94
DrugName rifampin
DrugDetail Rifampicin (INN) or rifampin (USAN) is a bactericidal antibiotic drug of the rifamycin group.It is a semisynthetic compound derived from Amycolatopsis rifamycinica (formerly known as Amycolatopsis mediterranei and Streptomyces mediterranei). Rifampicin inhibits DNA-dependent RNA polymerase in bacterial cells by binding its beta-subunit, thus preventing transcription to RNA and subsequent translation to proteins. Its lipophilic nature makes it a good candidate to treat the meningitis form of tuberculosis, which requires distribution to the central nervous system and penetration through the blood-brain barrier.

http://en.wikipedia.org/wiki/Rifampicin

Indication For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections.

http://www.drugbank.ca/drugs/DB01045

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Bacitracin Bacon AE, McGrath S, Fekety R, Holloway WJ. (1991) In vitro synergy studies with Clostridium difficile. Antimicrob Agents Chemother. 35(3):582-3.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
20-HETE synthase No
4-nitrophenol 2-hydroxylase No
Albendazole monooxygenase No
ATP-binding cassette sub-family B member 1 No
Cholesterol 7-alpha-hydroxylase No
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIIIA5 No
CYPIIIA7 No
Cytochrome P450 2A6 No
Cytochrome P450 3A43 No
DNA-directed RNA polymerase subunit beta Yes
DNA-directed RNA polymerase subunit beta' Yes
Nuclear receptor subfamily 1 group I member 2 No
DNA-directed RNA polymerase beta chain Yes
Orphan nuclear receptor PXR No
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor No
DNA-dependent RNA polymerase inhibitor, RNA synthesis inhibitor No
PathWay
PathWay Name Path Picture
pathway1
pathway2
pathway3