Detail for Rifabutin
Basic Information
DrugID 93
DrugName Rifabutin
DrugDetail Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant Mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae and M. avium intracellulare.

Indication For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Structure Click to see the orginal picture.
Drug Name PMIDLink Reference
Amphotericin B Clancy CJ, Yu YC, Lewin A, Nguyen MH. (1998) Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: demonstration of in vitro synergy between rifabutin and amphotericin B. Antimicrob Agents Chemother. 42(3):509-13.
PathWay Name Path Picture