Detail for Rifabutin
Basic Information
DrugID 93
DrugName Rifabutin
DrugDetail Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant Mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae and M. avium intracellulare.

http://en.wikipedia.org/wiki/Rifabutin

Indication For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

http://www.drugbank.ca/drugs/DB00615

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Clancy CJ, Yu YC, Lewin A, Nguyen MH. (1998) Inhibition of RNA synthesis as a therapeutic strategy against Aspergillus and Fusarium: demonstration of in vitro synergy between rifabutin and amphotericin B. Antimicrob Agents Chemother. 42(3):509-13.
Target
PathWay
PathWay Name Path Picture
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