Detail for Ribavirin
Basic Information
DrugID 92
DrugName Ribavirin
DrugDetail Ribavirin (brand names: Copegus, Rebetol, Ribasphere, Vilona and Virazole) is an anti-viral drug indicated for severe RSV infection (individually), hepatitis C infection (used in conjunction with peginterferon alfa-2b or peginterferon alfa-2a) and other viral infections. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is unknown; many mechanisms have been proposed for this but none of these has been proven to date. Multiple mechanisms may be responsible for its actions.

http://en.wikipedia.org/wiki/Ribavirin

Indication VIRAZOLE (ribavirin) is indicated for the treatment of hospitalized infants and young children with severe lower respiratory tract infections due to respiratory syncytial virus. Treatment early in the course of severe lower respiratory tract infection may be necessary to achieve efficacy.

http://www.rxlist.com/virazole-drug/indications-dosage.htm

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Ketoconazole Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Pentamidine Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Target
TargetName References EssentialGene? Link
5'-nucleotidase cytosolic II No
Adenosine kinase Yes
E-NPP 1 No
IMP dehydrogenase 2 Yes
Inosine-5'-monophosphate dehydrogenase 1 No
Large structural protein No
NPH I No
NPH II No
PB1 Yes
RNA-directed RNA polymerase catalytic subunit No
DNA Yes
Cytosolic purine 5'-nucleotidase No
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 No
RNA-directed RNA polymerase inhibitor No
PathWay
PathWay Name Path Picture
Purine metabolism - Reference pathway