Detail for ravuconazole
Basic Information
DrugID 90
DrugName ravuconazole
DrugDetail Ravuconazole (BMS-207147 and ER-30346) is a potent triazole antifungal, being developed by Bristol-Myers Squibb, that is currently in phase I/II clinical trials. The drug has a shown to have a similar spectrum of activity to voriconazole, with an increased half-life. However, ravuconazole has limited activity against species of fusarium, scedosporium and zygomycetes.

http://en.wikipedia.org/wiki/Ravuconazole

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Ortoneda M, Capilla J, Javier Pastor F, Pujol I, Guarro J. (2004) In vitro interactions of licensed and novel antifungal drugs against Fusarium spp. Diagn Microbiol Infect Dis. 48(1):69-71.
Terbinafine Ortoneda M, Capilla J, Pastor FJ, Pujol I, Yustes C, Serena C, Guarro J. (2004) In vitro interactions of approved and novel drugs against Paecilomyces spp. Antimicrob Agents Chemother. 48(7):2727-9.
Terbinafine Ortoneda M, Capilla J, Javier Pastor F, Pujol I, Guarro J. (2004) In vitro interactions of licensed and novel antifungal drugs against Fusarium spp. Diagn Microbiol Infect Dis. 48(1):69-71.
Cyclosporine Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Tacrolimus Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Rapamycin Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Anidulafungin Cuenca-Estrella M., Alastruey-Lzquierdo A., Alcazar-Fuoli L., Bernal-Martinez L., Gomez-Lopez A., Buitrago M.J., Mellado E., Rodriguez-Tudela J.L. (2008) In vitro activities of 35 double combinations of antifungal agents against Scedosporium apiospermum and Scedosporium prolificans. Antimicrobial Agents and Chemotherapy 52:1136-1139. DOI: 10.1128/aac.01160-07
Cyclosporine A Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
FK506 Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Target
TargetName References EssentialGene? Link
sterol 14alpha-demethylase ihibitor No
PathWay
PathWay Name Path Picture
pathway