Detail for Radicicol
Basic Information
DrugID 87
DrugName Radicicol
DrugDetail Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

Structure Click to see the orginal picture.
Drug Name PMIDLink Reference
Ketoconazole Zhang L.X., Yan K.Z., Zhang Y., Huang R., Bian J., Zheng C.S., Sun H.X., Chen Z.H., Sun N., An R., Min F.G., Zhao W.B., Zhuo Y., You J.L., Song Y.J., Yu Z.Y., Liu Z.H., Yang K.Q., Gao H., Dai H.Q., Zhang X.L., Wang J., Fu C.Z., Pei G., Liu J.T., Zhang S., Goodfellow M., Jiang Y.Y., Kuai J., Zhou G.C., Chen X.P. (2007) High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proceedings of the National Academy of Sciences of the United States of America 104:4606-4611. DOI: 10.1073/pnas.0609370104.