Detail for Posaconazole
Basic Information
DrugID 82
DrugName Posaconazole
DrugDetail Posaconazole is a triazole antifungal drug. Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system and thus inhibiting growth of the fungi. It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14??-demethylase and accumulation of methylated sterol precursors. Posaconazole is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.

http://en.wikipedia.org/wiki/Posaconazole

Indication For prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, Fusarium infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals.

http://www.drugbank.ca/drugs/DB01263

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Chaturvedi V, Ramani R, Andes D, Diekema DJ, Pfaller MA, Ghannoum MA, Knapp C, Lockhart SR, Ostrosky-Zeichner L, Walsh TJ, Marchillo K, Messer S, Welshenbaugh AR, Bastulli C, Iqbal N, Paetznick VL, Rodriguez J, Sein T. (2011) Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis. Antimicrob Agents Chemother. 55(4):1543-8.
Amphotericin B Perkhofer S, Locher M, Cuenca-Estrella M, R��chel R, W��rzner R, Dierich MP, Lass-Fl?rl C. (2008)enhances the activity of amphotericin B against hyphae of zygomycetes in vitro. Antimicrob Agents Chemother. 52(7):2636-8.
Amphotericin B Cacciapuoti A, Gurnani M, Halpern J, Norris C, Patel R, Loebenberg D. (2005) Interaction betweenand amphotericin B in concomitant treatment against Candida albicans in vivo. Antimicrob Agents Chemother. 49(2):638-42.
Amphotericin B Perkhofer S, Lugger H, Dierich MP, Lass-Fl?rl C. (2007)enhances the activity of amphotericin B against Aspergillus hyphae in vitro. Antimicrob Agents Chemother. 51(2):791-3.
Caspofungin Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. (2006) In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother. 50(6):2248-50.
Caspofungin Oliveira ER, Fothergill AW, Kirkpatrick WR, Coco BJ, Patterson TF, Redding SW. (2005) In vitro interaction ofand caspofungin against clinical isolates of Candida glabrata. Antimicrob Agents Chemother. 49(8):3544-5.
Caspofungin Guembe M, Guinea J, Pel��ez T, Torres-Narbona M, Bouza E. (2007) Synergistic effect ofand caspofungin against clinical zygomycetes. Antimicrob Agents Chemother. 51(9):3457-8.
Cyclosporine Dannaoui E, Schwarz P, Lortholary O. (2009) In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrob Agents Chemother. 53(8):3549-51.
Flucytosine Barchiesi F, Schimizzi AM, Najvar LK, Bocanegra R, Caselli F, Di Cesare S, Giannini D, Di Francesco LF, Giacometti A, Carle F, Scalise G, Graybill JR. (2001) Interactions ofand flucytosine against Cryptococcus neoformans. Antimicrob Agents Chemother. 45(5):1355-9.
Terbinafine Cuenca-Estrella M, Gomez-Lopez A, Buitrago MJ, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. (2006) In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis. Antimicrob Agents Chemother. 50(6):2248-50.
Caspofungin Oliveira E.R., Fothergill A.W., Kirkpatrick W.R., Coco B.J., Patterson T.F., Redding S.W. (2005) In vitro interaction ofand caspofungin against clinical isolates of Candida glabrata. Antimicrobial Agents and Chemotherapy 49:3544-3545. DOI: 10.1128/aac.49.8.3544-3545.2005.
Rapamycin Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Cyclosporine A Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Phenelzine 1
Target
TargetName References EssentialGene? Link
Lanosterol 14-alpha demethylase No
Cytochrome P450 51 No
sterol 14alpha-demethylase ihibitor No
PathWay
PathWay Name Path Picture
Steroid biosynthesis - Reference pathway (KO)