Detail for Perphenazine
Basic Information
DrugID 78
DrugName Perphenazine
DrugDetail Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. It has been in clinical use for decades. Perphenazine is roughly five times as potent as chlorpromazine; thus perphenazine is considered a medium-potency antipsychotic.

http://en.wikipedia.org/wiki/Perphenazine

Indication For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.

http://www.drugbank.ca/drugs/DB00850

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Phenazopyridine Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Tamoxifen Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
5-HT-7 No
Albendazole monooxygenase No
Alpha-1A adrenergic receptor No
Calmodulin Yes
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA No
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIID6 No
Cytochrome P450 Yes
Cytochrome P450 2C18 No
Cytochrome P450 2D6 No
Cytochrome P450 3A4 No
Cytochrome P450 CYP3A4 No
Cytochrome P450db1 No
D(1A) dopamine receptor Yes
D(2) dopamine receptor Yes
Sodium/potassium-transporting ATPase alpha-1 chain No
Sodium/potassium-transporting ATPase alpha-3 chain No
Sodium/potassium-transporting ATPase subunit alpha-1 Yes
Sodium/potassium-transporting ATPase subunit alpha-2 Yes
dopamine D2-receptor antagonist No
PathWay