Detail for Pentamidine
Basic Information
DrugID 77
DrugName Pentamidine
DrugDetail Pentamidine (formulated as a salt, pentamidine diisethionate or dimesilate) is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii), a severe interstitial type of pneumonia often seen in patients with HIV infection. The drug is also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis).

http://en.wikipedia.org/wiki/Pentamidine

Indication For the treatment of pneumonia due to Pneumocystis carinii.

http://www.drugbank.ca/drugs/DB00738

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Afeltra J, Dannaoui E, Meis JF, Rodriguez-Tudela JL, Verweij PE. (2002) In vitro synergistic interaction between amphotericin B andagainst Scedosporium prolificans. Antimicrob Agents Chemother. 46(10):3323-6.
Dacarbazine Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Pentolinium Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Phenazopyridine Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Ribavirin Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Tamoxifen Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Target
TargetName References EssentialGene? Link
Albendazole monooxygenase No
Beta-trypsin No
Chi-1 No
CYPIA2 Yes
CYPIIC8 No
CYPIID6 No
Glyceraldehyde-3-phosphate dehydrogenase Yes
HTH-type transcriptional regulator qacR No
Matriptase No
DNA Yes
tRNA Yes
PathWay