Detail for Miconazole
Basic Information
DrugID 70
DrugName Miconazole
DrugDetail Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. It can also be used against certain species of Leishmania protozoa which are a type of unicellular parasite that also contain ergosterol in their cell membranes. In addition to its antifungal and antiparasitic actions, it also has some limited antibacterial properties. It is marketed in various formulations under various brand names. Miconazole is also used in Ektachrome film developing in the final rinse of the Kodak E-6 process and similar Fuji CR-56 process, replacing formaldehyde. Fuji Hunt also includes miconazole as a final rinse additive in their formulation of the C-41RA rapid access color negative developing process.

http://en.wikipedia.org/wiki/Miconazole

Indication For topical application in the treatment of tinea pedis (athlete??s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.

http://www.drugbank.ca/drugs/DB01110

Structure
Interaction
Drug Name PMIDLink Reference
Amphotericin B Maesaki S, Kohno S, Kaku M, Koga H, Hara K. (1994) Effects of antifungal agent combinations administered simultaneously and sequentially against Aspergillus fumigatus. Antimicrob Agents Chemother. 38(12):2843-5.
Ibuprofen Scott EM, Tariq VN, McCrory RM. (1995) Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro. Antimicrob Agents Chemother. 39(12):2610-4.
nikkomycin X Hector RF, Schaller K. (1992) Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo. Antimicrob Agents Chemother. 36(6):1284-9.
nikkomycin Z Hector RF, Schaller K. (1992) Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo. Antimicrob Agents Chemother. 36(6):1284-9.
nitric oxide McElhaney-Feser GE, Raulli RE, Cihlar RL. (1998) Synergy of nitric oxide and azoles against Candida species in vitro. Antimicrob Agents Chemother. 42(9):2342-6.
Terbinafine Meletiadis J, Mouton JW, Meis JF, Verweij PE. (2003) In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Agents Chemother. 47(1):106-17.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
4-nitrophenol 2-hydroxylase No
Albendazole monooxygenase No
Aromatase Yes
ATP-binding cassette sub-family B member 1 No
Calcium-transporting ATPase type 2C member 1 No
Calmodulin Yes
Chymotrypsinogen A No
CYPIA2 Yes
CYPIIB6 No
CYPIID6 No
CYPLI No
CYPXIB1 No
Cytochrome P450 2A6 No
Heme oxygenase 1 Yes
Heme oxygenase 2 No
Lanosterol 14-alpha demethylase No
Malate dehydrogenase, cytoplasmic No
Cytochrome P450 51 No
Nitric-oxide synthase, endothelial No
Nitric oxide synthase, inducible Yes
Calcium-activated potassium channel subunit alpha 1 No
Calcium-activated potassium channel subunit beta-1 No
Calcium-activated potassium channel subunit beta 2 No
Calcium-activated potassium channel subunit beta-3 No
Calcium-activated potassium channel subunit beta-4 No
Intermediate conductance calcium-activated potassium channel protein 4 No
Small conductance calcium-activated potassium channel protein 1 No
Small conductance calcium-activated potassium channel protein 2 Yes
Small conductance calcium-activated potassium channel protein 3 Yes
Potassium voltage-gated channel subfamily H member 2 No
Potassium voltage-gated channel subfamily H member 6 No
Potassium voltage-gated channel subfamily H member 7 No
sterol 14alpha-demethylase ihibitor No
PathWay