Detail for Methoxsalen
Basic Information
DrugID 67
DrugName Methoxsalen
DrugDetail Methoxsalen (also called xanthotoxin, marketed under the trade names Oxsoralen, Deltasoralen, Meladinine) is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen is extracted from Ammi majus, a plant of the family Apiaceae. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10?mg tablets, which are taken in the amount of 30?mg 75?minutes before a PUVA (psoralen + UVA) light treatment. The substance is also present in other Apiaceae as well as Rutaceae, for example bergamot oil which is used in many perfumes and aromatherapy oils. Chemically, methoxsalen belongs to a class of organic natural molecules known as furanocoumarins. They consist of coumarin annulated with furan.

http://en.wikipedia.org/wiki/Methoxsalen

Indication For the treatment of psoriasis and vitiligo.

http://www.drugbank.ca/drugs/DB00553

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Tamoxifen Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
Target
TargetName References EssentialGene? Link
21-OHase No
Acetylcholinesterase Yes
Albendazole monooxygenase No
Amine oxidase [flavin-containing] A No
CYPIA1 No
CYPIA2 Yes
CYPIIA13 No
CYPIIA7 No
Cytochrome P450 2A6 No
Cytochrome P450 2E1 No
Steroid 21-hydroxylase No
DNA Yes
PathWay