Detail for Lovastatin
Basic Information
DrugID 65
DrugName Lovastatin
DrugDetail Lovastatin is a member of the drug class of statins, used for lowering cholesterol (hypolipidemic agent) in those with hypercholesterolemia and so preventing cardiovascular disease. Lovastatin is a naturally occurring drug found in food such as oyster mushrooms and red yeast rice.

http://en.wikipedia.org/wiki/Lovastatin

Indication For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. For primary prevention of coronary heart disease and to slow progression of coronary atherosclerosis in patients with coronary heart disease.

http://www.drugbank.ca/drugs/DB00227

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Voriconazole Chamilos G, Lewis RE, Kontoyiannis DP. (2006) Lovastatin has significant activity against zygomycetes and interacts synergistically with voriconazole. Antimicrob Agents Chemother. 50(1):96-103.
Fluconazole Song J.L., Lyons C.N., Holleman S., Oliver B.G., White T.C. (2003) Antifungal activity of fluconazole in combination with lovastatin and their effects on gene expression in the ergosterol and prenylation pathways in Candida albicans. Medical Mycology 41:417-425. DOI: 10.1080/1369378031000137233.
Ketoconazole Zhang L.X., Yan K.Z., Zhang Y., Huang R., Bian J., Zheng C.S., Sun H.X., Chen Z.H., Sun N., An R., Min F.G., Zhao W.B., Zhuo Y., You J.L., Song Y.J., Yu Z.Y., Liu Z.H., Yang K.Q., Gao H., Dai H.Q., Zhang X.L., Wang J., Fu C.Z., Pei G., Liu J.T., Zhang S., Goodfellow M., Jiang Y.Y., Kuai J., Zhou G.C., Chen X.P. (2007) High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proceedings of the National Academy of Sciences of the United States of America 104:4606-4611. DOI: 10.1073/pnas.0609370104.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
3-hydroxy-3-methylglutaryl-coenzyme A reductase Yes
Activator of G-protein signaling 1 No
Acyl coenzyme A:cholesterol acyltransferase No
Albendazole monooxygenase No
CD11 antigen-like family member A No
CD54 No
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA No
CYPIIC8 No
CYPIID6 No
CYPIIIA5 No
CYPIIIA7 No
Cytochrome P450 Yes
Cytochrome P450 3A4 No
Cytochrome P450 4F22 No
Cytochrome P450 CYP3A4 No
Putative uncharacterized protein No
Integrin alpha-L No
Histone deacetylase 2 No
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor No
PathWay