Detail for Lidocaine
Basic Information
DrugID 64
DrugName Lidocaine
DrugDetail Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.

http://en.wikipedia.org/wiki/Lidocaine

Indication For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.

http://www.drugbank.ca/drugs/DB00281

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Rodrigues AG, Araujo R, Pina-Vaz C. (2006) Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus. Int J Antimicrob Agents. 27(4):339-43.
Caspofungin Rodrigues AG, Araujo R, Pina-Vaz C. (2006) Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus. Int J Antimicrob Agents. 27(4):339-43.
Itraconazole Rodrigues AG, Araujo R, Pina-Vaz C. (2006) Interaction of local anaesthetics with other antifungal agents against pathogenic Aspergillus. Int J Antimicrob Agents. 27(4):339-43.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
Albendazole monooxygenase No
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA No
CYPIA2 Yes
CYPIIB6 No
CYPIIC8 No
CYPIID6 No
CYPIIIA5 No
CYPIIIA7 No
Cytochrome P450 Yes
Cytochrome P450 2A6 No
Cytochrome P450 2C18 No
Cytochrome P450 3A4 No
Cytochrome P450 CYP3A4 No
Epidermal growth factor receptor Yes
HH1 Yes
HK2 No
hNE-Na No
hPN3 No
Nav1.5 No
SCN5A protein No
Sodium channel protein type 10 subunit alpha No
Sodium channel protein type 5 subunit alpha No
Voltage-gated sodium channel type V alpha isoform b variant No
Sodium channel protein type 9 subunit alpha No
voltage-gated sodium channel (SCN1A) blocker No
voltage-gated sodium channel (SCN2A) blocker No
voltage-gated sodium channel (SCN3A) blocker No
voltage-gated sodium channel (SCN4A) blocker No
voltage-gated sodium channel (SCN5A) blocker No
voltage-gated sodium channel (SCN8A) blocker No
voltage-gated sodium channel (SCN9A) blocker No
voltage-gated sodium channel (SCN10A) blocker No
PathWay
PathWay Name Path Picture
pathway