Detail for lansoprazole
Basic Information
DrugID 62
DrugName lansoprazole
DrugDetail Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products. Lansoprazole has been marketed for many years and is one of several PPI’s available.

http://www.drugbank.ca/drugs/DB00448

Indication For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

http://www.drugbank.ca/drugs/DB00448

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Itraconazole Afeltra J, Vitale RG, Mouton JW, Verweij PE. (2004) Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole. Antimicrob Agents Chemother. 48(4):1335-43.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
20-HETE synthase No
Albendazole monooxygenase No
cDNA, FLJ93427, Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4(CYP3A4), transcript variant 1, mRNA No
CYP2C9 protein No
CYP2C9 protein No
CYPIA1 No
CYPIA2 Yes
CYPIIC8 No
CYPIID6 No
Cytochrome P450 Yes
Cytochrome P450 1B1 No
Cytochrome P-450 2C No
Cytochrome P450 2C18 No
Cytochrome P450 3A4 No
Cytochrome P450 CYP3A4 No
Cytochrome P-450 II C No
Cytochrome P450, family 2, subfamily C, polypeptide 9 No
Cytochrome p4502C9 No
Potassium-transporting ATPase alpha chain 1 No
H+/K+ exchanging, alpha polypeptide inhibitor No
H+/K+ exchanging, beta polypeptide inhibitor No
PathWay
PathWay Name Path Picture
pathway1
pathway2
pathway3