Detail for ibuprofen
Basic Information
DrugID 56
DrugName ibuprofen
DrugDetail Ibuprofen (INN) is a nonsteroidal anti-inflammatory drug (NSAID) used for relief of symptoms of arthritis, fever, as an analgesic (pain reliever), especially where there is an inflammatory component, and dysmenorrhea. Ibuprofen is known to have an antiplatelet effect, though it is relatively mild and somewhat short-lived when compared with aspirin or other better-known antiplatelet drugs. In general, ibuprofen also acts as a vasodilator, having been shown to dilate coronary arteries and some other blood vessels. Ibuprofen is a core medicine in the World Health Organization's "WHO Model List of Essential Medicines", which is a list of minimum medical needs for a basic healthcare system. Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. It was discovered by Andrew RM Dunlop, with colleagues Stewart Adams, John Nicholson, Vonleigh Simmons, Jeff Wilson and Colin Burrows, and was patented in 1961. Originally marketed as Brufen, ibuprofen is available under a variety of popular trademarks, including Motrin, Nurofen, Advil, and Nuprin.

http://en.wikipedia.org/wiki/Ibuprofen

Indication For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.

http://www.drugbank.ca/drugs/DB01050

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Econazole Tariq VN, Scott EM, McCain NE. (1995) Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, andagainst Candida albicans in vitro. Antimicrob Agents Chemother. 39(12):2615-9.
Fluconazole Scott EM, Tariq VN, McCrory RM. (1995) Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro. Antimicrob Agents Chemother. 39(12):2610-4.
Miconazole Scott EM, Tariq VN, McCrory RM. (1995) Demonstration of synergy with fluconazole and either ibuprofen, sodium salicylate, or propylparaben against Candida albicans in vitro. Antimicrob Agents Chemother. 39(12):2610-4.
Nikkomycin X Tariq VN, Scott EM, McCain NE. (1995) Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, andagainst Candida albicans in vitro. Antimicrob Agents Chemother. 39(12):2615-9.
Econazole Tariq V.N., Scott E.M., McCain N.E. (1995) Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, andagainst Candida albicans in vitro. Antimicrobial Agents and Chemotherapy 39:2615-2619
Nikkomycin Z Tariq V.N., Scott E.M., McCain N.E. (1995) Use of decimal assay for additivity to demonstrate synergy in pair combinations of econazole, nikkomycin Z, andagainst Candida albicans in vitro. Antimicrobial Agents and Chemotherapy 39:2615-2619
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
5-lipoxygenase No
Anandamide amidohydrolase 1 No
Arachidonate 5-lipoxygenase No
COX-1 Yes
COX-2 Yes
Cyclooxygenase 2b No
CYP2C9 protein No
CYPIIC8 No
Cytochrome P-450 2C No
Cytochrome P450, family 2, subfamily C, polypeptide 9 No
Cytochrome p4502C9 No
Fatty acid-binding protein, liver No
Prostaglandin G/H synthase 1 Yes
Prostaglandin G/H synthase 2 Yes
Putative cyclooxygenase-2 No
Serum albumin No
cyclooxygenase-1 (COX-1) inhibitor No
cyclooxygenase-2 (COX-2) inhibitor No
PathWay
PathWay Name Path Picture
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