Detail for Fluvastatin
Basic Information
DrugID 52
DrugName Fluvastatin
DrugDetail Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease. It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.

http://en.wikipedia.org/wiki/Fluvastatin

Indication To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia.

http://www.drugbank.ca/drugs/DB01095

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Fluconazole Chin NX, Weitzman I, Della-Latta P. (1997) In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans. Antimicrob Agents Chemother. 41(4):850-2.
Itraconazole Chin NX, Weitzman I, Della-Latta P. (1997) In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans. Antimicrob Agents Chemother. 41(4):850-2.
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
3-hydroxy-3-methylglutaryl-coenzyme A reductase Yes
AKT1 kinase Yes
Albendazole monooxygenase No
CYP2C9 protein No
CYPIA1 No
CYPIA2 Yes
CYPIIC8 No
CYPIID6 No
Cytochrome P-450 2C No
Cytochrome P450 2C8 No
Cytochrome P450, family 2, subfamily C, polypeptide 9 No
Cytochrome p4502C9 No
Mitogen-activated protein kinase 1 Yes
Mitogen-activated protein kinase 3 No
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor No
PathWay
PathWay Name Path Picture
pathway