Detail for Estradiol
Basic Information
DrugID 45
DrugName Estradiol
DrugDetail Estradiol (E2 or 17??-estradiol, also oestradiol) is a sex hormone. Estradiol is abbreviated E2 as it has 2 hydroxyl groups in its molecular structure. Estrone has 1 (E1) and estriol has 3 (E3). Estradiol is about 10 times as potent as estrone and about 80 times as potent as estriol in its estrogenic effect. Except during the early follicular phase of the menstrual cycle, its serum levels are somewhat higher than that of estrone during the reproductive years of the human female. Thus it is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity. During menopause, estrone is the predominant circulating estrogen and during pregnancy estriol is the predominant circulating estrogen in terms of serum levels. Estradiol is also present in males, being produced as an active metabolic product of testosterone. The serum levels of estradiol in males (14 - 55 pg/mL) are roughly comparable to those of postmenopausal women (< 35 pg/mL). Estradiol in vivo is interconvertible with estrone; estradiol to estrone conversion being favored. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs, including the bones.

Indication For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Structure Click to see the orginal picture.
Drug Name PMIDLink Reference
Dacarbazine Borisy A.A., Elliott P.J., Hurst N.W., Lee M.S., Lehar J., Price E.R., Serbedzija G., Zimmermann G.R., Foley M.A., Stockwell B.R., Keith C.T. (2003) Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America 100:7977-7982. DOI: 10.1073/pnas.1337088100.
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
Albendazole monooxygenase No
Androgen receptor Yes
Arylsulfatase C No
Cytochrome P450 1B1 No
ER Yes
ER-beta Yes
Estradiol 17-beta-dehydrogenase 1 No
Estrogen receptor Yes
Estrogen receptor beta Yes
Nuclear receptor subfamily 1 group I member 2 No
Steroid hormone receptor ERR1 No
Steroid hormone receptor ERR2 Yes
Orphan nuclear receptor PXR No
estrogen receptor 1 agonist No
estrogen receptor 2 agonist No