Detail for Cyclosporine A
Basic Information
DrugID 34
DrugName Cyclosporine A
DrugDetail Ciclosporin (INN/BAN), cyclosporine (USAN), cyclosporin (former BAN), or cyclosporin A is an immunosuppressant drug widely used in organ transplantation to prevent rejection. It reduces the activity of the immune system by interfering with the activity of T cells. Initially isolated from the fungus Tolypocladium inflatum isolated from a soil sample obtained by Sandoz scientists at Hardangervidda, Norway in 1970. Most peptides are synthesized by ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.

http://en.wikipedia.org/wiki/Cyclosporin_A

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Itraconazole Li Y., Sun S.J., Guo Q.J., Ma L., Shi C.W., Su L.Q., Li H.J. (2008) In vitro interaction between azoles and cyclosporin A against clinical isolates of Candida albicans determined by the chequerboard method and time-kill curves. Journal of Antimicrobial Chemotherapy 61:577-585. DOI: 10.1093/jac/dkm493.
Fenpropimorph Jansen G., Lee A.Y., Epp E., Fredette A., Surprenant J., Harcus D., Scott M., Tan E., Nishimura T., Whiteway M., Hallett M., Thomas D.Y. (2009) Chemogenomic profiling predicts antifungal synergies. Molecular Systems Biology 5. DOI: 10.1038/msb.2009.95.
Fluconazole Jansen G., Lee A.Y., Epp E., Fredette A., Surprenant J., Harcus D., Scott M., Tan E., Nishimura T., Whiteway M., Hallett M., Thomas D.Y. (2009) Chemogenomic profiling predicts antifungal synergies. Molecular Systems Biology 5. DOI: 10.1038/msb.2009.95.
Tunicamycin Jansen G., Lee A.Y., Epp E., Fredette A., Surprenant J., Harcus D., Scott M., Tan E., Nishimura T., Whiteway M., Hallett M., Thomas D.Y. (2009) Chemogenomic profiling predicts antifungal synergies. Molecular Systems Biology 5. DOI: 10.1038/msb.2009.95.
Voriconazole Jansen G., Lee A.Y., Epp E., Fredette A., Surprenant J., Harcus D., Scott M., Tan E., Nishimura T., Whiteway M., Hallett M., Thomas D.Y. (2009) Chemogenomic profiling predicts antifungal synergies. Molecular Systems Biology 5. DOI: 10.1038/msb.2009.95.
Ketoconazole Zhang L.X., Yan K.Z., Zhang Y., Huang R., Bian J., Zheng C.S., Sun H.X., Chen Z.H., Sun N., An R., Min F.G., Zhao W.B., Zhuo Y., You J.L., Song Y.J., Yu Z.Y., Liu Z.H., Yang K.Q., Gao H., Dai H.Q., Zhang X.L., Wang J., Fu C.Z., Pei G., Liu J.T., Zhang S., Goodfellow M., Jiang Y.Y., Kuai J., Zhou G.C., Chen X.P. (2007) High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proceedings of the National Academy of Sciences of the United States of America 104:4606-4611. DOI: 10.1073/pnas.0609370104.
Posaconazole Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Ravuconazole Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Target
PathWay