Detail for Cyclosporine
Basic Information
DrugID 33
DrugName Cyclosporine
DrugDetail Cyclosporin is a drug extracted from a fungus and used after organ transplantation to suppress the body's immune mechanisms, and so prevent rejection of an organ.It can suppresses the immune response by disabling helper T cells.

http://dictionary.reference.com/browse/cyclosporine

Indication For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis

http://www.drugbank.ca/drugs/DB00091

Structure
Interaction
Drug Name PMIDLink Reference
Amphotericin B Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, Del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Albert ND, Wagener MM, Singh N. (2008) Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrob Agents Chemother. 52(2):735-8.
Amphotericin B Dannaoui E, Schwarz P, Lortholary O. (2009) In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrob Agents Chemother. 53(8):3549-51.
Caspofungin Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. (2004) In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother. 48(5):1664-9.
Fluconazole Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, Del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Albert ND, Wagener MM, Singh N. (2008) Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrob Agents Chemother. 52(2):735-8.
Itraconazole Dannaoui E, Schwarz P, Lortholary O. (2009) In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrob Agents Chemother. 53(8):3549-51.
Posaconazole Dannaoui E, Schwarz P, Lortholary O. (2009) In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes. Antimicrob Agents Chemother. 53(8):3549-51.
ravuconazole Dannaoui E., Schwarz P., Lortholary O. (2009) In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes. Antimicrobial Agents and Chemotherapy 53:3549-3551. DOI: 10.1128/aac.00184-09
Target
TargetName References EssentialGene? Link
(R)-limonene 6-monooxygenase No
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase No
Albendazole monooxygenase No
ATP-binding cassette sub-family B member 1 No
Calcineurin subunit B type 2 No
Calcium signal-modulating cyclophilin ligand Yes
Canalicular multispecific organic anion transporter 1 No
CYPIA2 Yes
CYPIIC8 No
CYPIID6 No
CYPIIIA5 No
CYPIIIA7 No
DHOdehase No
FK506-binding protein 4 Yes
Peptidyl-prolyl cis-trans isomerase A Yes
Peptidyl-prolyl cis-trans isomerase B Yes
Photoreceptor No
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform No
Calcineurin subunit B isoform 2 No
Calcineurin inhibitor No
PathWay