Detail for Clotrimazole
Basic Information
| DrugID | 30 |
|---|---|
| DrugName | Clotrimazole |
| DrugDetail | Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. |
| Indication | For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch. |
| Structure |
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Interaction
| Drug Name | PMIDLink | Reference |
|---|---|---|
| 6-amino-2-n-pentylthiobenzothiazole | 10854813 | M��ckov�� M, Bujd��kov�� H, Kuchta T. (2000) Synergy between 6-amino-2-n-pentylthiobenzothiazole and ergosterol biosynthesis-inhibiting antimycotics against Candida albicans in vitro. Int J Antimicrob Agents. 15(2):153-4. |
| Nikkomycin X | 1416829 | Hector RF, Schaller K. (1992) Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo. Antimicrob Agents Chemother. 36(6):1284-9. |
| nikkomycin Z | 1416829 | Hector RF, Schaller K. (1992) Positive interaction of nikkomycins and azoles against Candida albicans in vitro and in vivo. Antimicrob Agents Chemother. 36(6):1284-9. |
Target
| TargetName | References | EssentialGene? | Link |
|---|---|---|---|
| (R)-limonene 6-monooxygenase | No | ||
| 4-nitrophenol 2-hydroxylase | No | ||
| Albendazole monooxygenase | No | ||
| Aromatase | Yes | http://tubic.tju.edu.cn/deg/information-e.php?ac=DEG20051986 | |
| ATP-binding cassette sub-family B member 1 | No | ||
| Beta-lactamase | No | ||
| Chymotrypsinogen A | No | ||
| CYPIA2 | Yes | http://tubic.tju.edu.cn/deg/information-e.php?ac=DEG20051109 | |
| CYPIIB6 | No | ||
| CYPIIC8 | No | ||
| CYPIID6 | No | ||
| CYPIIIA7 | No | ||
| CYPXIB1 | No | ||
| CYPXVII | Yes | http://tubic.tju.edu.cn/deg/information-e.php?ac=DEG20050104 | |
| Cytochrome P450 2A6 | No | ||
| Heme oxygenase 1 | Yes | http://tubic.tju.edu.cn/deg/information-e.php?ac=DEG20050143 | |
| Heme oxygenase 2 | No | ||
| Intermediate conductance calcium-activated potassium channel protein 4 | No | ||
| Lanosterol 14-alpha demethylase | No | ||
| Malate dehydrogenase, cytoplasmic | No | ||
| Cytochrome P450 51 | No | ||
| sterol 14alpha-demethylase ihibitor | No |
PathWay
| PathWay Name | Path Picture |
|---|---|
| pathway |
|