Detail for Ciprofloxacin
Basic Information
DrugID 27
DrugName Ciprofloxacin
DrugDetail Ciprofloxacin (INN) is a synthetic antibiotic of the fluoroquinolone drug class and is a broad-spectrum antimicrobial carboxyfluoroquinoline. It is a second-generation fluoroquinolone antibacterial. It kills bacteria by interfering with the enzymes that cause DNA to rewind after being copied, which stops synthesis of DNA and of protein.Ciprofloxacin has 12 FDA-approved human uses and other veterinary uses, but it is often used for unapproved uses (off-label). Ciprofloxacin interacts with other drugs, herbal and natural supplements, a characteristic it shares with other widely used antibacterial drugs such as amoxicillin, trimethoprim, azithromycin, cephalexin, and doxycycline.

http://www.drugbank.ca/drugs/DB00537

http://en.wikipedia.org/wiki/Ciprofloxacin

Indication For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).

http://www.drugbank.ca/drugs/DB00537

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Stergiopoulou T, Meletiadis J, Sein T, Papaioannidou P, Tsiouris I, Roilides E, Walsh TJ. (2008) Isobolographic analysis of pharmacodynamic interactions between antifungal agents and ciprofloxacin against Candida albicans and Aspergillus fumigatus. Antimicrob Agents Chemother. 52(6):2196-204.
Target
TargetName References EssentialGene? Link
Acriflavine resistance protein B No
Albendazole monooxygenase No
CYPIA2 Yes
DNA gyrase Yes
DNA gyrase subunit A Yes
DNA topoisomerase 2-alpha No
DNA topoisomerase 2-beta Yes
DNA topoisomerase 4 subunit A No
DNA topoisomerase IV Yes
Potassium voltage-gated channel subfamily H member 2 No
Serum albumin No
DNA gyrase inhibitor Yes
topoisomerase IV inhibitor No
PathWay
PathWay Name Path Picture
pathway