Detail for bacitracin
Basic Information
DrugID 13
DrugName bacitracin
DrugDetail Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn??t work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis.

Indication For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question.

Structure Click to see the orginal picture.
Drug Name PMIDLink Reference
Rifampin Bacon AE, McGrath S, Fekety R, Holloway WJ. (1991) In vitro synergy studies with Clostridium difficile. Antimicrob Agents Chemother. 35(3):582-3.
PathWay Name Path Picture