Detail for Azithromycin
Basic Information
DrugID 12
DrugName Azithromycin
DrugDetail Azithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.

http://www.drugbank.ca/drugs/DB00207

http://en.wikipedia.org/wiki/Azithromycin

Indication For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal

http://www.drugbank.ca/drugs/DB00207

Structure Click to see the orginal picture.
Interaction
Drug Name PMIDLink Reference
Amphotericin B Clancy CJ, Nguyen MH. (1998) The combination of amphotericin B and azithromycin as a potential new therapeutic approach to fusariosis. J Antimicrob Chemother. 41(1):127-30.
Amphotericin B Nguyen MH, Clancy CJ, Yu YC, Lewin AS. (1997) Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species. Eur J Clin Microbiol Infect Dis. 16(11):846-8.
Target
TargetName References EssentialGene? Link
50S ribosomal protein L10 Yes
50S ribosomal protein L22 Yes
50S ribosomal protein L4 Yes
Albendazole monooxygenase No
Cytochrome P450 2A6 No
DNA-binding factor KBF1 Yes
DNA-binding factor KBF2 No
Nuclear factor NF-kappa-B p65 subunit Yes
23S rRNA Yes
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor No
PathWay
PathWay Name Path Picture
pathway